Wilshere, who has overcome a succession of long-standing ankle injuries, dropped to the bench for Saturday's Barclays Premier League win at Fulham.
The midfielder will return to the starting XI for Tuesday night's Champions League qualifying second leg with Fenerbahce as the Gunners, leading 3-0 from the first match, bid to advance to the group stages.
Wenger said: "It made sense to give him a breather because we're playing every three days at the moment. He is not 100 per cent yet, but he is 90 per cent.
"I am a bit cautious because he had a few surgeries. I don't want to make a mistake on the medical front and overuse him because the ankle is the most important part of a football player.
"I would be a bit more cautious (than with another player), until we feel he is completely free from any risk."
Provided Wilshere comes through the Turkish test unscathed, he will also start against Tottenham on Sunday before going on international duty with England, who meet Moldova on Friday, September 6 and Ukraine the following Tuesday.
Wenger is aware of Wilshere's importance to England, whose manager Roy Hodgson announces his squad for the World Cup qualifiers on Tuesday.
Smiling, Wenger said: "(The Ukraine fixture is) the key. So don't play him against Moldova.
"It's World Cup year but first England have to qualify and we now go into a really important period for England. It's an important year for every single player because they all want to go to the World Cup.
Source: PA
Source: PA