Here, Press Association Sport takes a look at five classic past matches from this fixture.
Tottenham 2-1 Arsenal, February 2015
For many, this was the day Harry Kane truly came of age, the striker scoring twice as Spurs fought back from behind to win and move above Arsenal in the table
Kane's second, a towering header four minutes from time, proved a fitting end to a pulsating contest.
Arsenal 4-4 Tottenham, October 2008
Harry Redknapp's first game in charge at White Hart Lane ended all square but it felt like a win for Tottenham, who came from 4-2 down with goals from Jermaine Jenas and Aaron Lennon in the 89th and 94th minutes
David Bentley's early goal for Spurs, a dipping half-volley from 40 yards, was one of the best in this fixture's history.
Tottenham 4-5 Arsenal, November 2004
A nine-goal thriller ended with the Gunners on top as another new Spurs boss, Martin Jol, began his tenure with defeat in the capital
Arsenal's irresistible forward line proved too hot to handle as goals from Thierry Henry, Lauren, Patrick Vieira, Freddie Ljungberg and Robert Pires helped seal a memorable win.
Tottenham 2-3 Arsenal, September 1988
Arsenal won the First Division title in 1988-89 but this was far from a straight-forward victory, with all five goals coming in 12 minutes during a dizzying first half
If that was not strange enough, Paul Gascoigne scored the last goal bare footed after losing one of his boots in the build-up.
Arsenal 4-4 Tottenham, October 1963
In front of a near-68,000 crowd, Bill Nicholson's Tottenham stormed 4-2 up at half-time thanks to goals from Jimmy Greaves, Dave Mackay and a Bobby Smith double
Arsenal pulled one back, however, late on and then - with 20 seconds remaining - Geoff Strong completed another dramatic comeback.
Source : PA
Source: PA