Manager Arsene Wenger has been boosted by the news that international trio Thierry Henry, Sol Campbell and Dennis Bergkamp are all fit for the game.
Patrick Vieira and Sylvain Wiltord have both returned from France's international win in Cyprus unscathed but Ray Parlour and Lauren will miss out through injury.
The Gunners have a chance to equal the record of scoring in 44 consecutive top flight games.
And, as our head-to-head shows, Man City haven't won at Highbury since 4th October 1975.